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A lot of the inspiration for making this bird is from the Armstrong Whitworth Argosy and the DC-1; they're both such awe-inspiring works. I don't know, it just feels like biplanes went out of style as airliners before this sort of bird could have been built.
No flaps, no speed breaks, no activation groups, not a single light-bulb, turn the key and let 'er rip. Back then ya just hope she will stay in one piece til you get her back to the ground. That said, she is very stable... also the pitch aileron is mostly just for breaking after landing, as her trim is very effective

For take-off, engines to full, trim to half down around 110mph and watch her fly.

For landing, engines between 15% and 20% (depending on fuel levels), airspeed between 100mph and 105mph, trim around half down, perhaps lower. She will stabilize forgivingly, making landing approach very easy and requiring minimal effort. Upon touchdown (here is where timing is key), allow speed to fall to 95mph before applying breaks. As you allow speed to fall from 105 to 95, keep balance using trim, careful not to overcompensate or she will begin to climb and almost certainly stall. Apply breaks simultaneously with full pitch (that particular aileron is pretty much just there to be used to prevent her from tipping forward).