Wikipedia:

Ferrari achieved the 4.5-litre goal of the formula with the 375 F1, two of which debuted at Monza on September 3, 1950. This 4.5-litre (4493.73 cc/274 in³) engine produced roughly the same power as its 4.1-litre predecessor, but its tractability earned Ascari second place in that debut race. A series of modifications through the 1951 season allowed Ferrari to finally put Alfa Romeo behind it in a Formula One race, with José Froilán González' victory at Silverstone on July 14 becoming the constructor's first World Championship win. Ascari's wins at the Nürburgring and Monza and strong finishes throughout the season cemented the company's position as a Formula One contender.

Changes in the Formula One regulations led the company to shift the big engine to an Indy car, the 1952 375 Indianapolis. Three new Weber 40IF4C carburettors brought power output to 380 hp (279 kW), the wheelbase was lengthened, and the chassis and suspension were strengthened. Although the car performed well in European testing, it was not able to meet the American challenge, with just one of four 375s even qualifying for the 1952 Indianapolis 500. Ascari was the driver who did qualify the car for the race, starting 25th (out of 33 starters) with a qualifying speed of 134.3 mp/h (the pole was won by American Chet Miller who pushed his supercharged Kurtis Kraft-Novi to 139.03 mp/h). Ascari would be classified in 31st place, completing only 40 of the 200 laps before being forced to retire with wheel failure, though he would go on to win the remaining six Grands Prix of the season to easily win his first World Championship from Ferrari teammate Giuseppe Farina.

The big V12 was scrapped for 1954, as Formula One required a 2.5-litre engine. The new 553 F1 adopted Lampredi's four cylinder engine, leaving the V12 for sports car use.

The 375 was driven during the 2011 British Grand Prix weekend by then-current Ferrari driver Fernando Alonso as a tribute to the sixtieth anniversary of the Ferrari's first World Championship Grand Prix win at the 1951 British Grand Prix at Silverstone, with Argentinean driver José Froilán González driving at the time.

Screenshots:

Credit to Tucan for the beautiful screenshots!

Controls:

Pitch - Pull up to throttle forward and pull down to go in reverse, idk

Brake - Brake

Roll - Steer

AG1 - Open Hood

Some other info:
When you brake, the rims will still keep moving, for a while. I couldn't find a way to fix it, soooooo, Ye.

Didn't add suspension because it'd probably take a lot of time and wheel suspension doesn't work with custom rims.

Engine is not an exact replica of the actual Ferrari 375 F1 V12 engine.